Detalhe da pesquisa
1.
Population Pharmacokinetic Modeling of Free Plasma and Free Brain Concentrations of Ceftaroline in Healthy and Methicillin-Resistant Staphylococcus aureus-Infected Wistar Rats.
Antimicrob Agents Chemother
; 67(7): e0038223, 2023 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37367389
2.
Population Pharmacokinetic Model of Methotrexate in Brazilian Pediatric Patients with Acute Lymphoblastic Leukemia.
Pharm Res
; 40(7): 1777-1787, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37291462
3.
Population Pharmacokinetic Modeling and Probability of Target Attainment of Ceftaroline in Brain and Soft Tissues.
Antimicrob Agents Chemother
; 66(9): e0074122, 2022 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36005769
4.
Semi-Mechanistic Pharmacokinetic Modeling of Lipid Core Nanocapsules: Understanding Quetiapine Plasma and Brain Disposition in a Neurodevelopmental Animal Model of Schizophrenia.
J Pharmacol Exp Ther
; 375(1): 49-58, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32719070
5.
Efficacious Cefazolin Prophylactic Dose for Morbidly Obese Women Undergoing Bariatric Surgery Based on Evidence from Subcutaneous Microdialysis and Populational Pharmacokinetic Modeling.
Pharm Res
; 35(6): 116, 2018 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29644481
6.
Population Pharmacokinetic Modeling to Describe the Total Plasma and Free Brain Levels of Fluconazole in Healthy and Cryptococcus neoformans Infected Rats: How Does the Infection Impact the Drug's Levels on Biophase?
Pharm Res
; 35(7): 132, 2018 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29704215
7.
Leishmanicidal candidate LASSBio-1736, a cysteine protease inhibitor with favorable pharmacokinetics: low clearance and good distribution.
Xenobiotica
; 48(12): 1258-1267, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29160126
8.
Fast and sensitive HPLC/UV method for cefazolin quantification in plasma and subcutaneous tissue microdialysate of humans and rodents applied to pharmacokinetic studies in obese individuals.
Biomed Chromatogr
; 32(8): e4254, 2018 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-29656496
9.
Population Pharmacokinetic Modeling as a Tool To Characterize the Decrease in Ciprofloxacin Free Interstitial Levels Caused by Pseudomonas aeruginosa Biofilm Lung Infection in Wistar Rats.
Antimicrob Agents Chemother
; 61(7)2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28461311
10.
Influence of Experimental Cryptococcal Meningitis in Wistar Rats on Voriconazole Brain Penetration Assessed by Microdialysis.
Antimicrob Agents Chemother
; 61(7)2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28483963
11.
Simultaneous Semimechanistic Population Analyses of Levofloxacin in Plasma, Lung, and Prostate To Describe the Influence of Efflux Transporters on Drug Distribution following Intravenous and Intratracheal Administration.
Antimicrob Agents Chemother
; 60(2): 946-54, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26621623
12.
Pharmacokinetic Investigation of Quetiapine Transport across Blood-Brain Barrier Mediated by Lipid Core Nanocapsules Using Brain Microdialysis in Rats.
Mol Pharm
; 13(4): 1289-97, 2016 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26905300
13.
Population Pharmacokinetic Modeling of Etoposide Free Concentrations in Solid Tumor.
Pharm Res
; 33(7): 1657-70, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27068281
14.
Pharmacokinetics of hERG Channel Blocking Voacangine in Wistar Rats Applying a Validated LC-ESI-MS/MS Method.
Planta Med
; 82(11-12): 1030-8, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27257769
15.
Validation of a sensitive HPLC/fluorescence method for assessment of ciprofloxacin levels in plasma and prostate microdialysate samples from rats.
Biomed Chromatogr
; 30(3): 330-6, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26140501
16.
Simple HPLC-UV for the quantification of a new leishmanicidal candidate (E)-1-4(trifluoromethyl) benzylidene)-5-(2-4-dichlorozoyl) carbonylhydrazine (LASSBio-1736) in rat plasma for pharmacokinetics assessment.
Biomed Chromatogr
; 30(7): 1029-1035, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26542632
17.
HPLC-UV method for quantifying etoposide in plasma and tumor interstitial fluid by microdialysis: application to pharmacokinetic studies.
Biomed Chromatogr
; 29(4): 529-36, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25137530
18.
Determination of fexofenadine in Hank's balanced salt solution by high-performance liquid chromatography with ultraviolet detection: application to Caco-2 cell permeability studies.
Biomed Chromatogr
; 29(4): 537-44, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25159828
19.
Population pharmacokinetic modeling of the unbound levofloxacin concentrations in rat plasma and prostate tissue measured by microdialysis.
Antimicrob Agents Chemother
; 58(2): 678-86, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24217697
20.
Pre-clinical pharmacokinetics and acute toxicological evaluation of a monastrol derivative anticancer candidate LaSOM 65 in rats.
Xenobiotica
; 44(3): 254-63, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23937080